Modeling the dynamics of cardiac action potentials.

نویسندگان

  • G Duckett
  • D Barkley
چکیده

The nonlinear dynamics of cardiac action potentials is explained via simple model equations describing the membrane potential and the inward and outward currents through the membrane. The equations approximate ionic models, yet are expressed as polynomial functions, and robustly capture the phase-space dynamics of action potentials.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cardiovascular System Modeling

Mathematical models and numerical simulations of the cardiovascular system are very useful for understanding the mechanisms influencing its function and its physiological and pathological processes. This modeling research increases the potential for developing new diagnostic and therapeutic cardiovascular techniques or devices and is also helpful for pharmacological research [1]. The recent dev...

متن کامل

Irregularly appearing early afterdepolarizations in cardiac myocytes: random fluctuations or dynamical chaos?

Irregularly occurring early afterdepolarizations (EADs) in cardiac myocytes are traditionally hypothesized to be caused by random ion channel fluctuations. In this study, we combined 1), patch-clamp experiments in which action potentials were recorded at different pacing cycle lengths from isolated rabbit ventricular myocytes under several experimental conditions inducing EADs, including oxidat...

متن کامل

Nonlinear physics of electrical wave propagation in the heart: a review.

The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is triggered by a periodic sequence of electrical waves (action potentials) originating in the sino-atrial node and propagating over the atria and the ventricles. Cardiac arrhythmias like atrial and ventricular fibrillation (AF,VF) or ventricular tachycardia (VT) are caused by disruptions and instabilities of...

متن کامل

A Brief Look into Spike Sorting Methods

Spike sorting is a class of techniques used in the analysis of electrophysiological data. Studying the dynamics of neural activity via electrical recording relies on the ability to detect and sort neural spikes recorded from a number of neurons by the same electrode. This article reviews methods for detecting and classifying action potentials, a problem commonly referred to as spike sorting.

متن کامل

Impact of hypokinesia on dynamics of formation of evoked potentials in sensorimotor cortex in early postnatal ontogenesis

The analysis of evoked potentials of sensorimotor cortex in response to electrical stimulation of n. ischiadicus shows that the extremal factor hypokinesia has a negative impact on the dynamics of formation of amplitudal and temporal characteristics since eyes openning in 2-weeks old rats. The most vulnerable process to the impact of hypokinesia is the first-positive phase, which disappears in ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Physical review letters

دوره 85 4  شماره 

صفحات  -

تاریخ انتشار 2000